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Target Snapshot

CHEMBL4830 Target Snapshot

Growth factor receptor-bound protein 2 · SINGLE PROTEIN · Mus musculus

14Compounds
5Assays
1Approved Drugs
16.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q60631. Use UniProt Q60631 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q60631 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Growth factor receptor-bound protein 2 as ChEMBL target CHEMBL4830, mapped to UniProt Q60631. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Growth factor receptor-bound protein 2
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL4830
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q60631
Growth factor receptor-bound protein 2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Growth factor receptor-bound protein 2 is the right protein anchor across sources, using UniProt Q60631 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGrowth factor receptor-bound protein 2
UniProt AccessionQ60631
Component TypeProtein
Sequence Length217 aa

Growth factor receptor-bound protein 2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Growth factor receptor-bound protein 2, mapped to UniProt Q60631. Sequence length is 217 aa.

Mapped IDQ60631
Review nameGrowth factor receptor-bound protein 2
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5016.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2369548 6.3 IC50 500.0 Preclinical
CHEMBL2369547 6.1 IC50 800.0 Preclinical
CHEMBL2369549 6.1 IC50 800.0 Preclinical
CHEMBL2372234 6.05 IC50 900.0 Preclinical
CHEMBL2372235 6.0 IC50 1000.0 Preclinical
CHEMBL2372236 5.92 IC50 1200.0 Preclinical
CHEMBL2372231 5.82 IC50 1500.0 Preclinical
CHEMBL2372240 5.75 IC50 1800.0 Preclinical
CHEMBL2372239 5.7 IC50 2000.0 Preclinical
CHEMBL2372241 5.7 IC50 2000.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
5
5.5
5
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
13
Tested Compounds
2
Assay Types
Functional — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0
Binding — 2 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 13 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine