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Target Snapshot

CHEMBL4851 Target Snapshot

Serine/threonine-protein kinase 38-like · SINGLE PROTEIN · Homo sapiens

458Compounds
199Assays
1Approved Drugs
249.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9Y2H1. Use UniProt Q9Y2H1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9Y2H1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serine/threonine-protein kinase 38-like as ChEMBL target CHEMBL4851, mapped to UniProt Q9Y2H1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serine/threonine-protein kinase 38-like
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4851
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9Y2H1
Serine/threonine-protein kinase 38-like
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Serine/threonine-protein kinase 38-like is the right protein anchor across sources, using UniProt Q9Y2H1 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSerine/threonine-protein kinase 38-like
UniProt AccessionQ9Y2H1
Component TypeProtein
Sequence Length464 aa

Serine/threonine-protein kinase 38-like

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Serine/threonine-protein kinase 38-like, mapped to UniProt Q9Y2H1. Sequence length is 464 aa.

Mapped IDQ9Y2H1
Review nameSerine/threonine-protein kinase 38-like
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
4
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5013.0
KD236.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL388978 9.08 IC50 0.831 Preclinical
CHEMBL388978 7.55 Kd 28.0 Preclinical
CHEMBL603469 6.43 Kd 370.0 Clinical
CHEMBL574737 6.38 Kd 414.0 Clinical
CHEMBL509032 6.24 Kd 580.0 Preclinical
CHEMBL4465866 6.12 Kd 759.0 Preclinical
CHEMBL535 6.01 Kd 970.0 Approved
CHEMBL4097778 6.0 IC50 1000.0 Preclinical
CHEMBL1908397 5.96 Kd 1100.0 Preclinical
CHEMBL1721885 5.7 Kd 2000.0 Clinical
Distribution

pChEMBL Value Distribution

1
5.0
8
5.5
9
6.0
0
6.5
1
7.0
2
7.5
0
8.0
2
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

SUNITINIB
CHEMBL535
Approved 2006
Assay Landscape

Assay Landscape

199
Total Assays
14
Tested Compounds
1
Assay Types
Binding — 199 assays, 14 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 124 11 6.5
cell-based format 34 1 6.1
subcellular format 22 2 6.0
assay format 19 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine