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Target Snapshot

CHEMBL4879518 Target Snapshot

Microtubule-associated proteins 1A/1B light chain 3A · SINGLE PROTEIN · Homo sapiens

62Compounds
5Assays
3Approved Drugs
102.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9H492. Use UniProt Q9H492 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9H492 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Protein anchor
Microtubule-associated protein 1 light chain 3 alpha

Microtubule-associated protein 1 light chain 3 alpha

Review this target as Microtubule-associated proteins 1A/1B light chain 3A, mapped to UniProt Q9H492. ChEMBL maps the protein component as Microtubule-associated protein 1 light chain 3 alpha. Sequence length is 121 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt Q9H492 Protein 121 aa
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Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Microtubule-associated proteins 1A/1B light chain 3A as ChEMBL target CHEMBL4879518, mapped to UniProt Q9H492. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Microtubule-associated proteins 1A/1B light chain 3A
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4879518
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9H492
Microtubule-associated protein 1 light chain 3 alpha
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMicrotubule-associated protein 1 light chain 3 alpha
UniProt AccessionQ9H492
Component TypeProtein
Sequence Length121 aa

Microtubule-associated protein 1 light chain 3 alpha

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Microtubule-associated proteins 1A/1B light chain 3A, mapped to UniProt Q9H492. ChEMBL maps the protein component as Microtubule-associated protein 1 light chain 3 alpha. Sequence length is 121 aa.

Mapped IDQ9H492
Review nameMicrotubule-associated proteins 1A/1B light chain 3A
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC5035.0
KI61.0
KD6.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5556385 7.48 IC50 32.8 Preclinical
CHEMBL4851364 5.55 Kd 2800.0 Preclinical
CHEMBL4851364 5.48 Ki 3300.0 Preclinical
CHEMBL4852281 5.19 Ki 6400.0 Preclinical
CHEMBL4861964 5.14 Ki 7200.0 Preclinical
CHEMBL36506 5.12 Kd 7500.0 Approved
CHEMBL4878621 5.12 Ki 7500.0 Preclinical
CHEMBL36506 5.06 Ki 8800.0 Approved
CHEMBL4878719 5.06 Ki 8800.0 Preclinical
CHEMBL4856823 4.92 Ki 12000.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
1
5.5
0
6.0
0
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
62
Tested Compounds
1
Assay Types
Binding — 5 assays, 62 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 3 56 4.6
assay format 2 6 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine