Replicase polyprotein 1ab · SINGLE PROTEIN · Severe acute respiratory syndrome-related coronavirus
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As of 2026-09-14Protein identity stays anchored to UniProt P0C6X7. Use UniProt P0C6X7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P0C6X7 as the stable identity anchor, then attach disease evidence before program review.
Replicase polyprotein 1ab
Review this target as Replicase polyprotein 1ab, mapped to UniProt P0C6X7. Sequence length is 7073 aa.
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This review treats Replicase polyprotein 1ab as ChEMBL target CHEMBL5118, mapped to UniProt P0C6X7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Replicase polyprotein 1ab |
| Target Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| UniProt | P0C6X7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Replicase polyprotein 1ab |
| UniProt Accession | P0C6X7 |
| Component Type | Protein |
| Sequence Length | 7073 aa |
Replicase polyprotein 1ab
Review this target as Replicase polyprotein 1ab, mapped to UniProt P0C6X7. Sequence length is 7073 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5396377 | 9.85 | IC50 | 0.141 | Preclinical |
| CHEMBL5401656 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL4777223 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL4777223 | 8.31 | Ki | 4.94 | Preclinical |
| CHEMBL2435614 | 8.2 | Ki | 6.3 | Preclinical |
| CHEMBL497141 | 8.12 | Ki | 7.5 | Preclinical |
| CHEMBL5411560 | 7.29 | IC50 | 51.7 | Preclinical |
| CHEMBL213054 | 7.28 | Ki | 53.0 | Preclinical |
| CHEMBL5398458 | 7.23 | IC50 | 59.0 | Preclinical |
| CHEMBL5169323 | 7.21 | IC50 | 61.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 44 | 136 | 5.0 |
| single protein format | 17 | 72 | 5.5 |
| cell-based format | 4 | 21 | 4.8 |