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Evidence Snapshot

Replicase polyprotein 1ab

CHEMBL5118 SINGLE PROTEIN Severe acute respiratory syndrome-related coronavirus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T19:33:09Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5118
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Replicase polyprotein 1ab as ChEMBL target CHEMBL5118, mapped to UniProt P0C6X7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Replicase polyprotein 1ab
SINGLE PROTEIN · Severe acute respiratory syndrome-related coronavirus
As of 2026-09-13
ChEMBL target ID
CHEMBL5118
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P0C6X7
Replicase polyprotein 1ab
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Replicase polyprotein 1ab matters

As of 2026-09-13

Replicase polyprotein 1ab is reviewed as Replicase polyprotein 1ab (UniProt P0C6X7); the current evidence base includes 1 approved drug, 313 compounds, and 65 assays, with lead potency reaching pChEMBL 9.8.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 1 approved drug, 313 compounds, and 65 assays for this target. The dominant activity type is IC50. CHEMBL5396377 is the current potency anchor at pChEMBL 9.8.

Use CHEMBL5396377 as the tractability anchor when discussing potency (pChEMBL 9.8).

Activity source · ChEMBL 36 via Core Engine
1 approved pChEMBL 9.8
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Replicase polyprotein 1ab matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P0C6X7, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

313
Total Compounds
65
Total Assays
1
Approved Drugs
IC50: 264.0, KI: 50.0, EC50: 5.0, KD: 3.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL5396377
 9.8 IC50 —
No preferred name
CHEMBL5401656
 9.1 IC50 —
No preferred name
CHEMBL4777223
 8.4 IC50 —
No preferred name
CHEMBL4777223
 8.3 Ki —
No preferred name
CHEMBL2435614
 8.2 Ki —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T19:33:09Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5118