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Evidence Snapshot

Breakpoint cluster region protein

CHEMBL5146 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:14Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5146
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Breakpoint cluster region protein as ChEMBL target CHEMBL5146, mapped to UniProt P11274. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Breakpoint cluster region protein
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5146
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P11274
Breakpoint cluster region protein
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Breakpoint cluster region protein matters

As of 2026-09-14

Breakpoint cluster region protein is reviewed as Breakpoint cluster region protein (UniProt P11274); the current evidence base includes 17 approved drugs, 269 compounds, and 23 assays, with lead potency reaching pChEMBL 9.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 17 approved drugs, 269 compounds, and 23 assays for this target. The dominant activity type is KD. CHEMBL400402 is the current potency anchor at pChEMBL 9.0.

Use CHEMBL400402 as the tractability anchor when discussing potency (pChEMBL 9.0).

Activity source · ChEMBL 36 via Core Engine
17 approved pChEMBL 9.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Breakpoint cluster region protein matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P11274, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

269
Total Compounds
23
Total Assays
17
Approved Drugs
IC50: 23.0, KD: 244.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL400402
 9.0 Kd —
No preferred name
CHEMBL288441
 8.5 Kd Approved
No preferred name
CHEMBL3545085
 8.5 Kd —
No preferred name
CHEMBL402548
 8.3 Kd Clinical
No preferred name
CHEMBL5416410
 8.3 Kd Approved

Approved Drugs

Structure Compound First Approval
TOVORAFENIB
CHEMBL3348923
 2024
TIVOZANIB
CHEMBL1289494
 2017
NINTEDANIB
CHEMBL502835
 2014
BOSUTINIB
CHEMBL288441
 2012
PONATINIB
CHEMBL1171837
 2012
AXITINIB
CHEMBL1289926
 2012
CABOZANTINIB
CHEMBL2105717
 2012
REGORAFENIB
CHEMBL1946170
 2012
VANDETANIB
CHEMBL24828
 2011
NILOTINIB
CHEMBL255863
 2007
DASATINIB
CHEMBL5416410
 2006
IMATINIB
CHEMBL941
 2001
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:14Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5146