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Target Snapshot

CHEMBL5169156 Target Snapshot

Palmitoyltransferase ZDHHC20 · SINGLE PROTEIN · Homo sapiens

36Compounds
4Assays
0Approved Drugs
10.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q5W0Z9. Use UniProt Q5W0Z9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q5W0Z9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Palmitoyltransferase ZDHHC20 as ChEMBL target CHEMBL5169156, mapped to UniProt Q5W0Z9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Palmitoyltransferase ZDHHC20
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5169156
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q5W0Z9
Palmitoyltransferase ZDHHC20
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Palmitoyltransferase ZDHHC20 is the right protein anchor across sources, using UniProt Q5W0Z9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPalmitoyltransferase ZDHHC20
UniProt AccessionQ5W0Z9
Component TypeProtein
Sequence Length365 aa

Palmitoyltransferase ZDHHC20

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Palmitoyltransferase ZDHHC20, mapped to UniProt Q5W0Z9. Sequence length is 365 aa.

Mapped IDQ5W0Z9
Review namePalmitoyltransferase ZDHHC20
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5010.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5201039 5.87 IC50 1350.0 Preclinical
CHEMBL5186346 5.71 IC50 1970.0 Preclinical
CHEMBL5199102 5.54 IC50 2870.0 Preclinical
CHEMBL5191244 5.46 IC50 3430.0 Preclinical
CHEMBL5205503 5.46 IC50 3450.0 Preclinical
CHEMBL118417 5.26 IC50 5550.0 Preclinical
CHEMBL5181387 5.01 IC50 9730.0 Preclinical
CHEMBL5171728 4.67 IC50 21400.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
4
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

4
Total Assays
10
Tested Compounds
1
Assay Types
Binding — 4 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 8 5.4
single protein format 1 2 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine