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Target Snapshot

CHEMBL5272 Target Snapshot

Glycogen debranching enzyme · SINGLE PROTEIN · Homo sapiens

26Compounds
4Assays
2Approved Drugs
24.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P35573. Use UniProt P35573 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P35573 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glycogen debranching enzyme as ChEMBL target CHEMBL5272, mapped to UniProt P35573. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glycogen debranching enzyme
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5272
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P35573
Glycogen debranching enzyme
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Glycogen debranching enzyme is the right protein anchor across sources, using UniProt P35573 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlycogen debranching enzyme
UniProt AccessionP35573
Component TypeProtein
Sequence Length1532 aa

Glycogen debranching enzyme

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Glycogen debranching enzyme, mapped to UniProt P35573. Sequence length is 1532 aa.

Mapped IDP35573
Review nameGlycogen debranching enzyme
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC5024.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1088158 5.4 IC50 4000.0 Preclinical
CHEMBL80254 5.08 IC50 8400.0 Preclinical
CHEMBL312653 5.01 IC50 9800.0 Preclinical
CHEMBL1029 5.0 IC50 10000.0 Approved
CHEMBL1086997 5.0 IC50 10000.0 Clinical
CHEMBL110458 5.0 IC50 10000.0 Approved
CHEMBL307429 5.0 IC50 10000.0 Clinical
CHEMBL574645 5.0 IC50 10000.0 Preclinical
CHEMBL259905 4.96 IC50 11000.0 Preclinical
CHEMBL407337 4.96 IC50 11000.0 Preclinical
Distribution

pChEMBL Value Distribution

9
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

4
Total Assays
16
Tested Compounds
1
Assay Types
Binding — 4 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 16 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine