Compound Detail
CHEMBL259905
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Basic Information
| ChEMBL ID | CHEMBL259905 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PFYHYHZGDNWFIF-JGWLITMVSA-N |
2
Targets
9
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
163.2
MW (Da)
-2.97
ALogP
5
HBA
5
HBD
93.0
PSA (Ų)
0.30
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 9 meas. best 4.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen debranching enzyme CHEMBL5272 | IC50 | 4.96 | 4.96 | 11000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.55 | 4.55 | 28000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen debranching enzyme | IC50 | = | 11000.0 | nM | 4.96 | Inhibition of amylo-1,6-glucosidase | 18258441 |
| Unchecked | IC50 | = | 28000.0 | nM | 4.55 | Inhibition of yeast alpha-glucosidase | 18258441 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18258441 | 10.1016/j.bmc.2008.01.032 | Unchecked | 2 |
| 18258441 | 10.1016/j.bmc.2008.01.032 | Sucrase-isomaltase, intestinal | 2 |
| 16124768 | 10.1021/np050157a | Sucrase-isomaltase, intestinal | 2 |
| 18258441 | 10.1016/j.bmc.2008.01.032 | Glycogen debranching enzyme | 1 |
| 16124768 | 10.1021/np050157a | Lysosomal alpha-glucosidase | 1 |
| 16124768 | 10.1021/np050157a | Cytosolic beta-glucosidase | 1 |
| 16124768 | 10.1021/np050157a | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine