Cytochrome P450 2A6 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P11509. Use UniProt P11509 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P11509 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 2A6
Review this target as Cytochrome P450 2A6, mapped to UniProt P11509. Sequence length is 494 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 2A6 as ChEMBL target CHEMBL5282, mapped to UniProt P11509. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cytochrome P450 2A6 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P11509 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 2A6 |
| UniProt Accession | P11509 |
| Component Type | Protein |
| Sequence Length | 494 aa |
Cytochrome P450 2A6
Review this target as Cytochrome P450 2A6, mapped to UniProt P11509. Sequence length is 494 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3740883 | 10.24 | Ki | 0.057 | Preclinical |
| CHEMBL3740902 | 8.81 | Ki | 1.54 | Preclinical |
| CHEMBL3741757 | 8.76 | Ki | 1.73 | Preclinical |
| CHEMBL3739596 | 8.71 | Ki | 1.93 | Preclinical |
| CHEMBL3742224 | 8.59 | Ki | 2.57 | Preclinical |
| CHEMBL3742383 | 8.59 | Ki | 2.58 | Preclinical |
| CHEMBL3741819 | 8.57 | Ki | 2.7 | Preclinical |
| CHEMBL3740871 | 8.51 | Ki | 3.07 | Preclinical |
| CHEMBL3740860 | 8.48 | Ki | 3.27 | Preclinical |
| CHEMBL3740335 | 8.47 | Ki | 3.41 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 95 | 148 | 5.6 |
| microsome format | 48 | 41 | 6.2 |
| assay format | 44 | 22 | 7.8 |
| cell-based format | 8 | 1 | 4.3 |
| tissue-based format | 5 | 0 | — |
| cell membrane format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 15 | 120 | 5.5 |
| microsome format | 5 | 11 | 6.6 |
| assay format | 3 | 101 | 5.3 |
| cell-based format | 3 | 53 | 5.7 |