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Evidence Snapshot

Cytochrome P450 2A6

CHEMBL5282 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:13Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5282
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cytochrome P450 2A6 as ChEMBL target CHEMBL5282, mapped to UniProt P11509. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cytochrome P450 2A6
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL5282
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P11509
Cytochrome P450 2A6
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Cytochrome P450 2A6 matters

As of 2026-09-13

Cytochrome P450 2A6 is reviewed as Cytochrome P450 2A6 (UniProt P11509); the current evidence base includes 14 approved drugs, 1322 compounds, and 227 assays, with lead potency reaching pChEMBL 10.2.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 14 approved drugs, 1322 compounds, and 227 assays for this target. The dominant activity type is IC50. CHEMBL3740883 is the current potency anchor at pChEMBL 10.2.

Use CHEMBL3740883 as the tractability anchor when discussing potency (pChEMBL 10.2).

Activity source · ChEMBL 36 via Core Engine
14 approved pChEMBL 10.2
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Cytochrome P450 2A6 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P11509, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1322
Total Compounds
227
Total Assays
14
Approved Drugs
IC50: 1403.0, KI: 1059.0, KD: 19.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3740883
 10.2 Ki —
No preferred name
CHEMBL3740902
 8.8 Ki —
No preferred name
CHEMBL3741757
 8.8 Ki —
No preferred name
CHEMBL3739596
 8.7 Ki —
No preferred name
CHEMBL3742224
 8.6 Ki —

Approved Drugs

Structure Compound First Approval
TRANYLCYPROMINE
CHEMBL3989843
 1961
METHOXSALEN
CHEMBL416
 1954
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:13Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5282