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Target Snapshot

CHEMBL5320 Target Snapshot

Myotonin-protein kinase · SINGLE PROTEIN · Homo sapiens

678Compounds
208Assays
10Approved Drugs
155.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q09013. Use UniProt Q09013 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q09013 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Myotonin-protein kinase as ChEMBL target CHEMBL5320, mapped to UniProt Q09013. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Myotonin-protein kinase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5320
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q09013
Myotonin-protein kinase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Myotonin-protein kinase is the right protein anchor across sources, using UniProt Q09013 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMyotonin-protein kinase
UniProt AccessionQ09013
Component TypeProtein
Sequence Length629 aa

Myotonin-protein kinase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Myotonin-protein kinase, mapped to UniProt Q09013. Sequence length is 629 aa.

Mapped IDQ09013
Review nameMyotonin-protein kinase
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

10
Approved
5
Phase III
4
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5032.0
KD123.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL388978 8.46 Kd 3.5 Preclinical
CHEMBL5633837 7.52 Kd 30.0 Preclinical
CHEMBL3218297 7.47 IC50 34.06 Preclinical
CHEMBL607707 7.23 Kd 59.0 Clinical
CHEMBL4439133 7.19 IC50 64.6 Preclinical
CHEMBL4465866 7.05 Kd 90.0 Preclinical
CHEMBL288441 7.04 Kd 91.0 Approved
CHEMBL379218 7.04 Kd 92.0 Preclinical
CHEMBL4576489 7.03 Kd 94.0 Preclinical
CHEMBL388978 6.98 IC50 105.0 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
14
5.5
7
6.0
8
6.5
7
7.0
1
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

FEDRATINIB
CHEMBL1287853
Approved 2019
BOSUTINIB
CHEMBL288441
Approved 2012
Assay Landscape

Assay Landscape

208
Total Assays
35
Tested Compounds
1
Assay Types
Binding — 208 assays, 35 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 170 31 6.2
assay format 26 2 6.5
cell-based format 11 2 7.0
subcellular format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine