G-protein coupled bile acid receptor 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q8TDU6. Use UniProt Q8TDU6 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8TDU6 as the stable identity anchor, then attach disease evidence before program review.
G-protein coupled bile acid receptor 1
Review this target as G-protein coupled bile acid receptor 1, mapped to UniProt Q8TDU6. Sequence length is 330 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats G-protein coupled bile acid receptor 1 as ChEMBL target CHEMBL5409, mapped to UniProt Q8TDU6. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | G-protein coupled bile acid receptor 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8TDU6 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | G-protein coupled bile acid receptor 1 |
| UniProt Accession | Q8TDU6 |
| Component Type | Protein |
| Sequence Length | 330 aa |
G-protein coupled bile acid receptor 1
Review this target as G-protein coupled bile acid receptor 1, mapped to UniProt Q8TDU6. Sequence length is 330 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3793436 | 10.24 | EC50 | 0.057 | Preclinical |
| CHEMBL2181247 | 9.64 | EC50 | 0.23 | Preclinical |
| CHEMBL3290717 | 9.55 | EC50 | 0.28 | Preclinical |
| CHEMBL2336232 | 9.52 | EC50 | 0.3 | Preclinical |
| CHEMBL2181229 | 9.51 | EC50 | 0.31 | Preclinical |
| CHEMBL4779837 | 9.48 | EC50 | 0.33 | Preclinical |
| CHEMBL5270816 | 9.37 | EC50 | 0.43 | Preclinical |
| CHEMBL3290716 | 9.35 | EC50 | 0.45 | Preclinical |
| CHEMBL2181227 | 9.34 | EC50 | 0.46 | Preclinical |
| CHEMBL2181228 | 9.22 | EC50 | 0.6 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 152 | 785 | 6.5 |
| assay format | 10 | 20 | 7.1 |
| single protein format | 2 | 1 | 5.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 30 | 79 | 7.3 |
| single protein format | 15 | 16 | 6.8 |
| assay format | 9 | 322 | 6.7 |
| tissue-based format | 1 | 1 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 1 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 3 | 6.4 |
| cell-based format | 1 | 3 | 6.8 |