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Evidence Snapshot

G-protein coupled bile acid receptor 1

CHEMBL5409 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T19:50:25Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5409
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats G-protein coupled bile acid receptor 1 as ChEMBL target CHEMBL5409, mapped to UniProt Q8TDU6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
G-protein coupled bile acid receptor 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL5409
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q8TDU6
G-protein coupled bile acid receptor 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why G-protein coupled bile acid receptor 1 matters

As of 2026-09-13

G-protein coupled bile acid receptor 1 is reviewed as G-protein coupled bile acid receptor 1 (UniProt Q8TDU6); the current evidence base includes 12 approved drugs, 1525 compounds, and 225 assays, with lead potency reaching pChEMBL 10.2.

Protein context
G-protein coupled bile acid receptor 1

G-protein coupled bile acid receptor 1 Sequence length is 330 aa.

Review this target as G-protein coupled bile acid receptor 1, mapped to UniProt Q8TDU6. Sequence length is 330 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt Q8TDU6 Protein
Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 12 approved drugs, 1525 compounds, and 225 assays for this target. The dominant activity type is EC50. CHEMBL3793436 is the current potency anchor at pChEMBL 10.2.

Use CHEMBL3793436 as the tractability anchor when discussing potency (pChEMBL 10.2).

Activity source · ChEMBL 36 via Core Engine
12 approved pChEMBL 10.2
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why G-protein coupled bile acid receptor 1 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q8TDU6, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1525
Total Compounds
225
Total Assays
12
Approved Drugs
IC50: 34.0, EC50: 1559.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3793436
 10.2 EC50 —
No preferred name
CHEMBL2181247
 9.6 EC50 —
No preferred name
CHEMBL3290717
 9.6 EC50 —
No preferred name
CHEMBL2336232
 9.5 EC50 —
No preferred name
CHEMBL2181229
 9.5 EC50 —

Approved Drugs

Structure Compound First Approval
OBETICHOLIC ACID
CHEMBL566315
 2016
DEOXYCHOLIC ACID
CHEMBL406393
 2015
PREDNISOLONE
CHEMBL131
 1955
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T19:50:25Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5409