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Target Snapshot

CHEMBL5570 Target Snapshot

Macrophage colony-stimulating factor 1 receptor · SINGLE PROTEIN · Mus musculus

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415Compounds
77Assays
3Approved Drugs
487.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P09581. Use UniProt P09581 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P09581 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Macrophage colony-stimulating factor 1 receptor as ChEMBL target CHEMBL5570, mapped to UniProt P09581. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Macrophage colony-stimulating factor 1 receptor
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL5570
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P09581
Macrophage colony-stimulating factor 1 receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Macrophage colony-stimulating factor 1 receptor is the right protein anchor across sources, using UniProt P09581 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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Preferred NameMacrophage colony-stimulating factor 1 receptor
Target TypeSINGLE PROTEIN
OrganismMus musculus
UniProtP09581
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMacrophage colony-stimulating factor 1 receptor
UniProt AccessionP09581
Component TypeProtein
Sequence Length977 aa

Macrophage colony-stimulating factor 1 receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Macrophage colony-stimulating factor 1 receptor, mapped to UniProt P09581. Sequence length is 977 aa.

Mapped IDP09581
Review nameMacrophage colony-stimulating factor 1 receptor
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

3
Approved
2
Phase III
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50486.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3674575 9.39 IC50 0.41 Preclinical
CHEMBL3674563 9.38 IC50 0.42 Preclinical
CHEMBL3929497 9.38 IC50 0.42 Preclinical
CHEMBL3639734 9.37 IC50 0.43 Preclinical
CHEMBL3086320 9.36 IC50 0.44 Preclinical
CHEMBL3674560 9.33 IC50 0.47 Preclinical
CHEMBL3958852 9.31 IC50 0.49 Preclinical
CHEMBL3965172 9.3 IC50 0.5 Preclinical
CHEMBL3897660 9.25 IC50 0.56 Preclinical
CHEMBL492809 9.22 IC50 0.6 Preclinical
Distribution

pChEMBL Value Distribution

11
5.0
9
5.5
14
6.0
33
6.5
79
7.0
80
7.5
95
8.0
80
8.5
46
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PEXIDARTINIB
CHEMBL3813873
Approved 2019
Properties Compare Identifier
NILOTINIB
CHEMBL255863
Approved 2007
Properties Compare Identifier
SUNITINIB
CHEMBL535
Approved 2006
Properties Compare Identifier
Assay Landscape

Assay Landscape

77
Total Assays
394
Tested Compounds
2
Assay Types
Binding — 57 assays, 394 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 46 131 7.1
single protein format 10 263 8.2
assay format 1 0 —
Functional — 20 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 20 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine