Review anchor
Macrophage colony-stimulating factor 1 receptor
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
Evidence Snapshot
Macrophage colony-stimulating factor 1 receptor
CHEMBL5570
SINGLE PROTEIN
Mus musculus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Macrophage colony-stimulating factor 1 receptor as ChEMBL target CHEMBL5570, mapped to UniProt P09581. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL5570
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P09581
Macrophage colony-stimulating factor 1 receptor
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Macrophage colony-stimulating factor 1 receptor matters
Macrophage colony-stimulating factor 1 receptor is reviewed as Macrophage colony-stimulating factor 1 receptor (UniProt P09581); the current evidence base includes 3 approved drugs, 415 compounds, and 77 assays, with lead potency reaching pChEMBL 9.4.
Protein context
Macrophage colony-stimulating factor 1 receptor
Macrophage colony-stimulating factor 1 receptor Sequence length is 977 aa.
Review this target as Macrophage colony-stimulating factor 1 receptor, mapped to UniProt P09581. Sequence length is 977 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P09581
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 3 approved drugs, 415 compounds, and 77 assays for this target. The dominant activity type is IC50. CHEMBL3674575 is the current potency anchor at pChEMBL 9.4.
Use CHEMBL3674575 as the tractability anchor when discussing potency (pChEMBL 9.4).
Activity source · ChEMBL 36 via Core Engine
3 approved
pChEMBL 9.4
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Macrophage colony-stimulating factor 1 receptor matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P09581, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
415
Total Compounds
77
Total Assays
3
Approved Drugs
IC50: 486.0, KD: 1.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL3674575
|
9.4 | IC50 | — |
|
|
No preferred name
CHEMBL3674563
|
9.4 | IC50 | — |
|
|
No preferred name
CHEMBL3929497
|
9.4 | IC50 | — |
|
|
No preferred name
CHEMBL3639734
|
9.4 | IC50 | — |
|
|
No preferred name
CHEMBL3086320
|
9.4 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
PEXIDARTINIB
CHEMBL3813873
|
2019 |
|
|
NILOTINIB
CHEMBL255863
|
2007 |
|
|
SUNITINIB
CHEMBL535
|
2006 |
Source Header