Rhodopsin kinase GRK1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q15835. Use UniProt Q15835 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q15835 as the stable identity anchor, then attach disease evidence before program review.
Rhodopsin kinase GRK1
Review this target as Rhodopsin kinase GRK1, mapped to UniProt Q15835. Sequence length is 563 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Rhodopsin kinase GRK1 as ChEMBL target CHEMBL5607, mapped to UniProt Q15835. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Rhodopsin kinase GRK1 is the right protein anchor across sources, using UniProt Q15835 as the stable mapping.
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| Preferred Name | Rhodopsin kinase GRK1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q15835 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Rhodopsin kinase GRK1 |
| UniProt Accession | Q15835 |
| Component Type | Protein |
| Sequence Length | 563 aa |
Rhodopsin kinase GRK1
Review this target as Rhodopsin kinase GRK1, mapped to UniProt Q15835. Sequence length is 563 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 9.01 | Kd | 0.97 | Preclinical |
| CHEMBL603469 | 7.62 | Kd | 24.0 | Clinical |
| CHEMBL4877302 | 7.28 | IC50 | 52.0 | Preclinical |
| CHEMBL388978 | 7.24 | IC50 | 57.8 | Preclinical |
| CHEMBL3809796 | 7.16 | IC50 | 70.0 | Preclinical |
| CHEMBL608533 | 7.07 | Kd | 85.0 | Approved |
| CHEMBL4576489 | 6.96 | Kd | 109.0 | Preclinical |
| CHEMBL4465866 | 6.91 | Kd | 122.0 | Preclinical |
| CHEMBL101892 | 6.75 | Ki | 180.0 | Preclinical |
| CHEMBL4854871 | 6.72 | IC50 | 190.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 100 | 45 | 5.8 |
| assay format | 16 | 0 | — |
| cell-based format | 6 | 4 | 6.5 |