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Evidence Snapshot

Cysteinyl leukotriene receptor 1

CHEMBL5645 SINGLE PROTEIN Cavia porcellus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:40Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5645
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cysteinyl leukotriene receptor 1 as ChEMBL target CHEMBL5645, mapped to UniProt Q2NNR5. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cysteinyl leukotriene receptor 1
SINGLE PROTEIN · Cavia porcellus
As of 2026-09-14
ChEMBL target ID
CHEMBL5645
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q2NNR5
Cysteinyl leukotriene receptor 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Cysteinyl leukotriene receptor 1 matters

As of 2026-09-14

Cysteinyl leukotriene receptor 1 is reviewed as Cysteinyl leukotriene receptor 1 (UniProt Q2NNR5); the current evidence base includes 6 approved drugs, 599 compounds, and 121 assays, with lead potency reaching pChEMBL 10.4.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 6 approved drugs, 599 compounds, and 121 assays for this target. The dominant activity type is KI. CHEMBL21333 is the current potency anchor at pChEMBL 10.4.

Use CHEMBL21333 as the tractability anchor when discussing potency (pChEMBL 10.4).

Activity source · ChEMBL 36 via Core Engine
6 approved pChEMBL 10.4
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Cysteinyl leukotriene receptor 1 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q2NNR5, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

599
Total Compounds
121
Total Assays
6
Approved Drugs
IC50: 225.0, KI: 321.0, KD: 38.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL21333
 10.4 IC50 Approved
No preferred name
CHEMBL47430
 10.0 Ki —
No preferred name
CHEMBL46663
 9.9 Ki —
No preferred name
CHEMBL15177
 9.7 Ki —
No preferred name
CHEMBL275357
 9.7 IC50 —

Approved Drugs

Structure Compound First Approval
MONTELUKAST
CHEMBL787
 1998
ZAFIRLUKAST
CHEMBL603
 1996
PRANLUKAST
CHEMBL21333
 1995
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:40Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL5645