Serine/threonine-protein kinase Nek3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P51956. Use UniProt P51956 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P51956 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase Nek3
Review this target as Serine/threonine-protein kinase Nek3, mapped to UniProt P51956. Sequence length is 506 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase Nek3 as ChEMBL target CHEMBL5679, mapped to UniProt P51956. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Serine/threonine-protein kinase Nek3 is the right protein anchor across sources, using UniProt P51956 as the stable mapping.
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| Preferred Name | Serine/threonine-protein kinase Nek3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P51956 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase Nek3 |
| UniProt Accession | P51956 |
| Component Type | Protein |
| Sequence Length | 506 aa |
Serine/threonine-protein kinase Nek3
Review this target as Serine/threonine-protein kinase Nek3, mapped to UniProt P51956. Sequence length is 506 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL475251 | 6.77 | Kd | 170.0 | Clinical |
| CHEMBL5575113 | 6.61 | IC50 | 245.0 | Preclinical |
| CHEMBL1078178 | 6.54 | Kd | 286.0 | Approved |
| CHEMBL3545328 | 6.45 | Kd | 353.0 | Preclinical |
| CHEMBL1287853 | 6.19 | Kd | 640.0 | Approved |
| CHEMBL513909 | 6.14 | Kd | 720.0 | Clinical |
| CHEMBL1976040 | 6.08 | Kd | 837.0 | Clinical |
| CHEMBL482967 | 6.08 | Kd | 830.0 | Preclinical |
| CHEMBL4088216 | 6.0 | IC50 | 1000.0 | Preclinical |
| CHEMBL4097778 | 6.0 | IC50 | 1000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 120 | 15 | 5.7 |
| assay format | 17 | 0 | — |
| subcellular format | 15 | 11 | 5.7 |
| cell-based format | 13 | 0 | — |