Mitogen-activated protein kinase kinase kinase 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9Y2U5. Use UniProt Q9Y2U5 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Y2U5 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase kinase kinase 2
Review this target as Mitogen-activated protein kinase kinase kinase 2, mapped to UniProt Q9Y2U5. Sequence length is 619 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase kinase kinase 2 as ChEMBL target CHEMBL5914, mapped to UniProt Q9Y2U5. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Mitogen-activated protein kinase kinase kinase 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y2U5 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase kinase kinase 2 |
| UniProt Accession | Q9Y2U5 |
| Component Type | Protein |
| Sequence Length | 619 aa |
Mitogen-activated protein kinase kinase kinase 2
Review this target as Mitogen-activated protein kinase kinase kinase 2, mapped to UniProt Q9Y2U5. Sequence length is 619 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 8.62 | Kd | 2.4 | Preclinical |
| CHEMBL603469 | 8.32 | Kd | 4.8 | Clinical |
| CHEMBL502835 | 8.03 | Kd | 9.4 | Approved |
| CHEMBL4554938 | 7.72 | Kd | 19.0 | Preclinical |
| CHEMBL388978 | 7.63 | IC50 | 23.5 | Preclinical |
| CHEMBL288441 | 7.52 | Kd | 30.0 | Approved |
| CHEMBL4465866 | 7.42 | Kd | 38.0 | Preclinical |
| CHEMBL1789941 | 7.39 | Kd | 41.0 | Approved |
| CHEMBL4576489 | 7.28 | Kd | 53.0 | Preclinical |
| CHEMBL535 | 7.24 | Kd | 57.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 138 | 41 | 6.7 |
| subcellular format | 30 | 16 | 5.9 |
| cell-based format | 29 | 4 | 6.5 |
| assay format | 21 | 0 | — |