Serine/threonine-protein kinase MARK1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9P0L2. Use UniProt Q9P0L2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9P0L2 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase MARK1
Review this target as Serine/threonine-protein kinase MARK1, mapped to UniProt Q9P0L2. Sequence length is 795 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase MARK1 as ChEMBL target CHEMBL5940, mapped to UniProt Q9P0L2. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serine/threonine-protein kinase MARK1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9P0L2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase MARK1 |
| UniProt Accession | Q9P0L2 |
| Component Type | Protein |
| Sequence Length | 795 aa |
Serine/threonine-protein kinase MARK1
Review this target as Serine/threonine-protein kinase MARK1, mapped to UniProt Q9P0L2. Sequence length is 795 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 9.58 | IC50 | 0.261 | Preclinical |
| CHEMBL5305160 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4576489 | 8.52 | Kd | 3.0 | Preclinical |
| CHEMBL388978 | 8.4 | Kd | 4.0 | Preclinical |
| CHEMBL4116008 | 8.4 | IC50 | 4.0 | Clinical |
| CHEMBL4465866 | 8.05 | Kd | 9.0 | Preclinical |
| CHEMBL3605057 | 7.57 | IC50 | 27.0 | Preclinical |
| CHEMBL509032 | 7.51 | Kd | 31.0 | Preclinical |
| CHEMBL603469 | 7.08 | Kd | 83.0 | Clinical |
| CHEMBL1940251 | 6.96 | IC50 | 110.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 246 | 33 | 6.5 |
| assay format | 45 | 0 | — |
| cell-based format | 22 | 2 | 8.3 |
| subcellular format | 9 | 0 | — |