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Target Snapshot

CHEMBL5941 Target Snapshot

Serine/threonine-protein kinase 26 · SINGLE PROTEIN · Homo sapiens

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1,373Compounds
354Assays
10Approved Drugs
553.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q9P289. Use UniProt Q9P289 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9P289 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serine/threonine-protein kinase 26 as ChEMBL target CHEMBL5941, mapped to UniProt Q9P289. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serine/threonine-protein kinase 26
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL5941
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9P289
Serine/threonine-protein kinase 26
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Serine/threonine-protein kinase 26 is the right protein anchor across sources, using UniProt Q9P289 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSerine/threonine-protein kinase 26
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9P289
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSerine/threonine-protein kinase 26
UniProt AccessionQ9P289
Component TypeProtein
Sequence Length416 aa

Serine/threonine-protein kinase 26

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Serine/threonine-protein kinase 26, mapped to UniProt Q9P289. Sequence length is 416 aa.

Mapped IDQ9P289
Review nameSerine/threonine-protein kinase 26
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

10
Approved
7
Phase III
5
Phase II
8
Phase I
Assay Mix

Activity Type Distribution

IC50134.0
EC5054.0
KD365.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL388978 8.54 IC50 2.87 Preclinical
CHEMBL514409 8.22 IC50 6.0 Preclinical
CHEMBL4568087 8.2 IC50 6.3 Preclinical
CHEMBL180022 8.15 IC50 7.0 Approved
CHEMBL180022 8.13 Kd 7.4 Approved
CHEMBL1084546 7.92 Kd 12.0 Preclinical
CHEMBL2105728 7.89 Kd 13.0 Clinical
CHEMBL482967 7.89 Kd 13.0 Preclinical
CHEMBL4554938 7.8 Kd 16.0 Preclinical
CHEMBL3128043 7.77 Kd 17.0 Preclinical
Distribution

pChEMBL Value Distribution

26
5.0
32
5.5
23
6.0
16
6.5
7
7.0
12
7.5
4
8.0
2
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

NERATINIB
CHEMBL180022
Approved 2017
Properties Compare Identifier
NINTEDANIB
CHEMBL502835
Approved 2014
Properties Compare Identifier
BOSUTINIB
CHEMBL288441
Approved 2012
Properties Compare Identifier
SUNITINIB
CHEMBL535
Approved 2006
Properties Compare Identifier
Assay Landscape

Assay Landscape

354
Total Assays
111
Tested Compounds
1
Assay Types
Binding — 354 assays, 111 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 261 44 6.3
cell-based format 47 44 5.6
assay format 29 5 6.6
subcellular format 17 18 6.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine