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Target Snapshot

CHEMBL6054 Target Snapshot

PAS domain-containing serine/threonine-protein kinase · SINGLE PROTEIN · Homo sapiens

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1,667Compounds
205Assays
0Approved Drugs
3,013.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q96RG2. Use UniProt Q96RG2 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q96RG2 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats PAS domain-containing serine/threonine-protein kinase as ChEMBL target CHEMBL6054, mapped to UniProt Q96RG2. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
PAS domain-containing serine/threonine-protein kinase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL6054
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q96RG2
PAS domain-containing serine/threonine-protein kinase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether PAS domain-containing serine/threonine-protein kinase is the right protein anchor across sources, using UniProt Q96RG2 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NamePAS domain-containing serine/threonine-protein kinase
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ96RG2
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPAS domain-containing serine/threonine-protein kinase
UniProt AccessionQ96RG2
Component TypeProtein
Sequence Length1323 aa

PAS domain-containing serine/threonine-protein kinase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as PAS domain-containing serine/threonine-protein kinase, mapped to UniProt Q96RG2. Sequence length is 1323 aa.

Mapped IDQ96RG2
Review namePAS domain-containing serine/threonine-protein kinase
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase I
Assay Mix

Activity Type Distribution

IC502,760.0
KI85.0
KD168.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL388978 8.26 IC50 5.54 Preclinical
CHEMBL2000832 6.9 Ki 125.89 Preclinical
CHEMBL1967116 6.9 Ki 125.89 Preclinical
CHEMBL1993722 6.6 Ki 251.19 Preclinical
CHEMBL1970104 6.6 Ki 251.19 Preclinical
CHEMBL225519 6.6 Ki 251.19 Preclinical
CHEMBL3775576 6.58 IC50 260.0 Preclinical
CHEMBL2005936 6.5 Ki 316.23 Preclinical
CHEMBL1979577 6.4 Ki 398.11 Preclinical
CHEMBL50894 6.4 Ki 398.11 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
6
5.5
13
6.0
8
6.5
0
7.0
2
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

205
Total Assays
19
Tested Compounds
2
Assay Types
Binding — 204 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 145 7 6.4
cell-based format 31 0 —
assay format 27 4 5.3
subcellular format 1 1 6.0
Functional — 1 assays, 19 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 19 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine