Triple specificity protein phosphatase PtpB · SINGLE PROTEIN · Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
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As of 2026-09-14Protein identity stays anchored to UniProt I6WXK4. Use UniProt I6WXK4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt I6WXK4 as the stable identity anchor, then attach disease evidence before program review.
Triple specificity protein phosphatase PtpB
Review this target as Triple specificity protein phosphatase PtpB, mapped to UniProt I6WXK4. Sequence length is 276 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Triple specificity protein phosphatase PtpB as ChEMBL target CHEMBL6066201, mapped to UniProt I6WXK4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Triple specificity protein phosphatase PtpB |
| Target Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| UniProt | I6WXK4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Triple specificity protein phosphatase PtpB |
| UniProt Accession | I6WXK4 |
| Component Type | Protein |
| Sequence Length | 276 aa |
Triple specificity protein phosphatase PtpB
Review this target as Triple specificity protein phosphatase PtpB, mapped to UniProt I6WXK4. Sequence length is 276 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4637373 | 8.39 | IC50 | 4.1 | Preclinical |
| CHEMBL4647367 | 8.19 | IC50 | 6.4 | Preclinical |
| CHEMBL4638011 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL4649112 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL4637459 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL4641106 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL5848788 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL4647032 | 7.6 | IC50 | 25.0 | Preclinical |
| CHEMBL4645770 | 7.58 | IC50 | 26.0 | Preclinical |
| CHEMBL4649838 | 7.57 | IC50 | 27.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 25 | 6.1 |
| single protein format | 2 | 36 | 6.9 |