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Target Snapshot

CHEMBL6066579 Target Snapshot

Apoptosis regulator Bcl-2/Beclin-1 · PROTEIN COMPLEX · Homo sapiens

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52Compounds
2Assays
0Approved Drugs
53.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P10415. Use UniProt P10415 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P10415 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Apoptosis regulator Bcl-2/Beclin-1 as ChEMBL target CHEMBL6066579, mapped to UniProt P10415. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Apoptosis regulator Bcl-2/Beclin-1
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL6066579
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P10415
Apoptosis regulator Bcl-2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Apoptosis regulator Bcl-2/Beclin-1 is the right protein anchor across sources, using UniProt P10415 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameApoptosis regulator Bcl-2/Beclin-1
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtP10415
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelApoptosis regulator Bcl-2
UniProt AccessionP10415
Component TypeProtein
Sequence Length239 aa

Apoptosis regulator Bcl-2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Apoptosis regulator Bcl-2/Beclin-1, mapped to UniProt P10415. ChEMBL maps the protein component as Apoptosis regulator Bcl-2. Sequence length is 239 aa.

Mapped IDP10415
Review nameApoptosis regulator Bcl-2/Beclin-1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase I
Assay Mix

Activity Type Distribution

IC5053.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5203263 7.2 IC50 63.0 Preclinical
CHEMBL5201326 6.74 IC50 184.0 Preclinical
CHEMBL5188416 6.56 IC50 274.0 Preclinical
CHEMBL5179160 6.46 IC50 349.0 Preclinical
CHEMBL5196601 6.34 IC50 455.0 Preclinical
CHEMBL5757533 6.04 IC50 905.0 Preclinical
CHEMBL5184993 6.01 IC50 982.0 Preclinical
CHEMBL5822152 5.91 IC50 1244.0 Preclinical
CHEMBL5204089 5.78 IC50 1676.0 Preclinical
CHEMBL376408 5.77 IC50 1700.0 Preclinical
Distribution

pChEMBL Value Distribution

9
5.0
14
5.5
5
6.0
2
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
38
Tested Compounds
1
Assay Types
Binding — 2 assays, 38 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 2 38 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine