Thymidylate synthase · SINGLE PROTEIN · Escherichia coli
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As of 2026-09-13Protein identity stays anchored to UniProt C3SWJ7. Use UniProt C3SWJ7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt C3SWJ7 as the stable identity anchor, then attach disease evidence before program review.
Thymidylate synthase
Review this target as Thymidylate synthase, mapped to UniProt C3SWJ7. Sequence length is 264 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thymidylate synthase as ChEMBL target CHEMBL6137, mapped to UniProt C3SWJ7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Thymidylate synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Escherichia coli |
| UniProt | C3SWJ7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thymidylate synthase |
| UniProt Accession | C3SWJ7 |
| Component Type | Protein |
| Sequence Length | 264 aa |
Thymidylate synthase
Review this target as Thymidylate synthase, mapped to UniProt C3SWJ7. Sequence length is 264 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL360335 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL362606 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL425692 | 8.82 | Ki | 1.5 | Preclinical |
| CHEMBL422395 | 8.52 | Ki | 3.0 | Preclinical |
| CHEMBL25889 | 8.32 | Ki | 4.8 | Preclinical |
| CHEMBL169411 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL169921 | 8.1 | Ki | 8.0 | Preclinical |
| CHEMBL360758 | 8.03 | Ki | 9.4 | Preclinical |
| CHEMBL886 | 8.0 | Ki | 10.0 | Preclinical |
| CHEMBL168524 | 7.96 | Ki | 11.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 106 | 210 | 5.7 |