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Evidence Snapshot

Thymidylate synthase

CHEMBL6137 SINGLE PROTEIN Escherichia coli
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T08:31:18Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL6137
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Thymidylate synthase as ChEMBL target CHEMBL6137, mapped to UniProt C3SWJ7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Thymidylate synthase
SINGLE PROTEIN · Escherichia coli
As of 2026-09-13
ChEMBL target ID
CHEMBL6137
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
C3SWJ7
Thymidylate synthase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Thymidylate synthase matters

As of 2026-09-13

Thymidylate synthase is reviewed as Thymidylate synthase (UniProt C3SWJ7); the current evidence base includes 3 approved drugs, 379 compounds, and 106 assays, with lead potency reaching pChEMBL 9.5.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 3 approved drugs, 379 compounds, and 106 assays for this target. The dominant activity type is IC50. CHEMBL360335 is the current potency anchor at pChEMBL 9.5.

Use CHEMBL360335 as the tractability anchor when discussing potency (pChEMBL 9.5).

Activity source · ChEMBL 36 via Core Engine
3 approved pChEMBL 9.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Thymidylate synthase matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt C3SWJ7, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

379
Total Compounds
106
Total Assays
3
Approved Drugs
IC50: 236.0, KI: 98.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL360335
 9.5 Ki —
No preferred name
CHEMBL362606
 9.5 Ki —
No preferred name
CHEMBL425692
 8.8 Ki —
No preferred name
CHEMBL422395
 8.5 Ki —
No preferred name
CHEMBL25889
 8.3 Ki —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T08:31:18Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL6137