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Evidence Snapshot

MDCK

CHEMBL614068 CELL-LINE Canis lupus familiaris
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:38:54Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL614068
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MDCK as ChEMBL target CHEMBL614068. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MDCK
CELL-LINE · Canis lupus familiaris
As of 2026-09-13
ChEMBL target ID
CHEMBL614068
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why MDCK matters

As of 2026-09-13

MDCK is reviewed as MDCK; the current evidence base includes 9 approved drugs, 7304 compounds, and 1343 assays, with lead potency reaching pChEMBL 7.7.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 9 approved drugs, 7304 compounds, and 1343 assays for this target. The dominant activity type is IC50. CHEMBL373114 is the current potency anchor at pChEMBL 7.7.

Use CHEMBL373114 as the tractability anchor when discussing potency (pChEMBL 7.7).

Activity source · ChEMBL 36 via Core Engine
9 approved pChEMBL 7.7
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why MDCK matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

7304
Total Compounds
1343
Total Assays
9
Approved Drugs
IC50: 560.0, EC50: 89.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL373114
 7.7 IC50 —
No preferred name
CHEMBL222813
 7.4 EC50 Approved
No preferred name
CHEMBL4566346
 6.6 IC50 —
No preferred name
CHEMBL53463
 6.4 IC50 Approved
No preferred name
CHEMBL334007
 6.2 IC50 —

Approved Drugs

Structure Compound First Approval
ZANAMIVIR
CHEMBL222813
 1999
DOXORUBICIN
CHEMBL53463
 1974
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:38:54Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL614068