THP-1 · CELL-LINE · Homo sapiens
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THP-1
Review this target as THP-1.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats THP-1 as ChEMBL target CHEMBL614245. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | THP-1 |
| Target Type | CELL-LINE |
| Organism | Homo sapiens |
Reviewable protein naming and mapping context for this target snapshot.
Review this target as THP-1.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4636181 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL432374 | 9.96 | IC50 | 0.11 | Preclinical |
| CHEMBL4649732 | 9.9 | IC50 | 0.1259 | Preclinical |
| CHEMBL3893393 | 9.8 | IC50 | 0.1585 | Preclinical |
| CHEMBL4638451 | 9.7 | IC50 | 0.1995 | Preclinical |
| CHEMBL328242 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL5618885 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL1092012 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL419134 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL2170284 | 9.43 | IC50 | 0.37 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1,824 | 2,568 | 6.2 |
| organism-based format | 8 | 0 | — |
| cell-free format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 374 | 562 | 4.8 |
| organism-based format | 5 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 119 | 67 | 4.8 |