Review anchor
THP-1
CELL-LINE · Homo sapiens
As of 2026-09-13
Evidence Snapshot
THP-1
CHEMBL614245
CELL-LINE
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats THP-1 as ChEMBL target CHEMBL614245. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL614245
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why THP-1 matters
THP-1 is reviewed as THP-1; the current evidence base includes 59 approved drugs, 8236 compounds, and 2329 assays, with lead potency reaching pChEMBL 10.0.
Protein context
THP-1
THP-1
Review this target as THP-1.
Protein source · UniProt accession via ChEMBL component mappingDisease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 59 approved drugs, 8236 compounds, and 2329 assays for this target. The dominant activity type is IC50. CHEMBL4636181 is the current potency anchor at pChEMBL 10.0.
Use CHEMBL4636181 as the tractability anchor when discussing potency (pChEMBL 10.0).
Activity source · ChEMBL 36 via Core Engine
59 approved
pChEMBL 10.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why THP-1 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
8236
Total Compounds
2329
Total Assays
59
Approved Drugs
IC50: 4501.0, KI: 1.0, EC50: 603.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL4636181
|
10.0 | IC50 | — |
|
|
No preferred name
CHEMBL432374
|
10.0 | IC50 | — |
|
|
No preferred name
CHEMBL4649732
|
9.9 | IC50 | — |
|
|
No preferred name
CHEMBL3893393
|
9.8 | IC50 | — |
|
|
No preferred name
CHEMBL4638451
|
9.7 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
QUIZARTINIB
CHEMBL576982
|
2023 |
|
|
ABEMACICLIB
CHEMBL3301610
|
2017 |
|
|
VENETOCLAX
CHEMBL3137309
|
2016 |
|
|
PANOBINOSTAT
CHEMBL483254
|
2015 |
|
|
BELINOSTAT
CHEMBL408513
|
2014 |
|
|
TOFACITINIB
CHEMBL221959
|
2012 |
|
|
NILOTINIB
CHEMBL255863
|
2007 |
|
|
SUNITINIB
CHEMBL535
|
2006 |
|
|
VORINOSTAT
CHEMBL98
|
2006 |
|
|
SORAFENIB
CHEMBL1336
|
2005 |
|
|
GEMCITABINE
CHEMBL888
|
1996 |
|
|
VINORELBINE
CHEMBL553025
|
1994 |
|
|
PACLITAXEL
CHEMBL428647
|
1992 |
|
|
ETOPOSIDE
CHEMBL44657
|
1983 |
|
|
MITOMYCIN
CHEMBL105
|
1981 |
|
|
PROBUCOL
CHEMBL608
|
1977 |
|
|
DOXORUBICIN
CHEMBL53463
|
1974 |
|
|
THIOGUANINE
CHEMBL727
|
1966 |
|
|
INDOMETHACIN
CHEMBL6
|
1965 |
|
|
FLUOROURACIL
CHEMBL185
|
1962 |
|
|
BETAMETHASONE
CHEMBL632
|
1961 |
|
|
COLCHICINE
CHEMBL107
|
1961 |
|
|
DEXAMETHASONE
CHEMBL384467
|
1958 |
|
|
DISULFIRAM
CHEMBL964
|
1951 |
Source Header