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Evidence Snapshot

ZR-75-1

CHEMBL614393 CELL-LINE Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T11:12:50Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL614393
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats ZR-75-1 as ChEMBL target CHEMBL614393. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
ZR-75-1
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614393
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why ZR-75-1 matters

As of 2026-09-13

ZR-75-1 is reviewed as ZR-75-1; the current evidence base includes 17 approved drugs, 812 compounds, and 282 assays, with lead potency reaching pChEMBL 9.6.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 17 approved drugs, 812 compounds, and 282 assays for this target. The dominant activity type is IC50. CHEMBL67 is the current potency anchor at pChEMBL 9.6.

Use CHEMBL67 as the tractability anchor when discussing potency (pChEMBL 9.6).

Activity source · ChEMBL 36 via Core Engine
17 approved pChEMBL 9.6
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why ZR-75-1 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

812
Total Compounds
282
Total Assays
17
Approved Drugs
IC50: 247.0, KI: 6.0, EC50: 58.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL67
 9.6 IC50 —
No preferred name
CHEMBL2441610
 9.3 IC50 —
No preferred name
CHEMBL3128043
 9.3 IC50 —
No preferred name
CHEMBL3037931
 9.3 IC50 —
No preferred name
CHEMBL2441607
 9.2 IC50 —

Approved Drugs

Structure Compound First Approval
CAPIVASERTIB
CHEMBL2325741
 2023
ABEMACICLIB
CHEMBL3301610
 2017
NILUTAMIDE
CHEMBL1274
 1996
PACLITAXEL
CHEMBL428647
 1992
FLUDARABINE PHOSPHATE
CHEMBL1096882
 1991
AMSACRINE
CHEMBL43
 1987
ETOPOSIDE
CHEMBL44657
 1983
DOXORUBICIN
CHEMBL53463
 1974
VINBLASTINE
CHEMBL159
 1965
VINCRISTINE
CHEMBL90555
 1963
COLCHICINE
CHEMBL107
 1961
METHOTREXATE
CHEMBL34259
 1953
EMETINE
CHEMBL50588
 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T11:12:50Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL614393