Assay Detail
Binding
CHEMBL1000138
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Displacement of [3H]prazosin from adrenergic alpha1 receptor in rat cortical membrane
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.89 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140287 | — | — | 1 | 6.29 |
| CHEMBL138900 | — | — | 1 | 6.23 |
| CHEMBL485729 | — | — | 1 | 6.15 |
| CHEMBL521350 | — | — | 1 | 6.11 |
| CHEMBL485929 | — | — | 1 | 6.11 |
| CHEMBL485728 | — | — | 1 | 5.65 |
| CHEMBL139848 | — | — | 1 | 5.29 |
| CHEMBL487360 | — | — | 1 | 5.26 |
| CHEMBL487359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140287 | — | Ki | = | 512.0 | nM | 6.29 |
| CHEMBL138900 | — | Ki | = | 585.0 | nM | 6.23 |
| CHEMBL485729 | — | Ki | = | 712.0 | nM | 6.15 |
| CHEMBL521350 | — | Ki | = | 783.0 | nM | 6.11 |
| CHEMBL485929 | — | Ki | = | 786.0 | nM | 6.11 |
| CHEMBL485728 | — | Ki | = | 2250.0 | nM | 5.65 |
| CHEMBL139848 | — | Ki | = | 5160.0 | nM | 5.29 |
| CHEMBL487360 | — | Ki | = | 5540.0 | nM | 5.26 |
| CHEMBL487359 | — | Ki | > | 850.0 | nM | - |