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Compound Detail

CHEMBL485728

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COc1cccc([C@H]2CC[C@@H](N3CCN(c4ccccc4)CC3)CC2)c1

Basic Information

ChEMBL ID CHEMBL485728
Phase Preclinical
Structure Type MOL
InChI Key XCLCSOAFYUDOLP-IQGASKDCSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

350.5
MW (Da)
4.54
ALogP
3
HBA
0
HBD
15.7
PSA (Ų)
0.80
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H30N2O
MW 350.51
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -0.95

Activity Summary

Ki 4 meas. best 6.74

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 1A
CHEMBL273
Ki 6.74 6.74 183.0 1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
CHEMBL5525
Ki 5.77 5.77 1710.0 1
Adrenergic receptor alpha-1
CHEMBL1907610
Ki 5.65 5.65 2250.0 1
D(2) dopamine receptor
CHEMBL339
Ki 5.62 5.62 2380.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19053780 10.1021/jm800965b 5-hydroxytryptamine receptor 1A 1
19053780 10.1021/jm800965b D(2) dopamine receptor 1
19053780 10.1021/jm800965b Adrenergic receptor alpha-1 1
19053780 10.1021/jm800965b 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1
19053780 10.1021/jm800965b PC-3 1

Data from ChEMBL 36 via Core Engine