Assay Detail
Binding
CHEMBL1000139
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](-)-(S)-emopamil from EBP in guinea pig liver membrane
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (CHEMBL5525) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.35 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457722 | — | — | 1 | 8.30 |
| CHEMBL456435 | — | — | 1 | 8.30 |
| CHEMBL513936 | — | — | 1 | 8.15 |
| CHEMBL457720 | — | — | 1 | 8.14 |
| CHEMBL485729 | — | — | 1 | 8.09 |
| CHEMBL53325 | — | — | 1 | 8.08 |
| CHEMBL457508 | — | — | 1 | 8.04 |
| CHEMBL486136 | — | — | 1 | 7.87 |
| CHEMBL190883 | — | — | 1 | 7.84 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 7.79 |
| CHEMBL511857 | — | — | 1 | 7.79 |
| CHEMBL487360 | — | — | 1 | 7.78 |
| CHEMBL456437 | — | — | 1 | 7.78 |
| CHEMBL487359 | — | — | 1 | 7.63 |
| CHEMBL138900 | — | — | 1 | 7.49 |
| CHEMBL511680 | — | — | 1 | 7.48 |
| CHEMBL485929 | — | — | 1 | 7.48 |
| CHEMBL521350 | — | — | 1 | 7.34 |
| CHEMBL457731 | — | — | 1 | 7.33 |
| CHEMBL458553 | — | — | 1 | 7.31 |
| CHEMBL458361 | — | — | 1 | 7.14 |
| CHEMBL458802 | — | — | 1 | 7.07 |
| CHEMBL457721 | — | — | 1 | 6.97 |
| CHEMBL511507 | — | — | 1 | 6.85 |
| CHEMBL139848 | — | — | 1 | 6.34 |
| CHEMBL75228 | 1-PHENETHYLPIPERIDINE | — | 1 | 6.22 |
| CHEMBL485728 | — | — | 1 | 5.77 |
| CHEMBL140287 | — | — | 1 | 5.58 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 5.12 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457722 | — | Ki | = | 4.95 | nM | 8.30 |
| CHEMBL456435 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL513936 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL457720 | — | Ki | = | 7.21 | nM | 8.14 |
| CHEMBL485729 | — | Ki | = | 8.15 | nM | 8.09 |
| CHEMBL53325 | — | Ki | = | 8.38 | nM | 8.08 |
| CHEMBL457508 | — | Ki | = | 9.04 | nM | 8.04 |
| CHEMBL486136 | — | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL190883 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL305187 | IFENPRODIL | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL511857 | — | Ki | = | 16.2 | nM | 7.79 |
| CHEMBL487360 | — | Ki | = | 16.7 | nM | 7.78 |
| CHEMBL456437 | — | Ki | = | 16.8 | nM | 7.78 |
| CHEMBL487359 | — | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL138900 | — | Ki | = | 32.1 | nM | 7.49 |
| CHEMBL511680 | — | Ki | = | 33.1 | nM | 7.48 |
| CHEMBL485929 | — | Ki | = | 32.8 | nM | 7.48 |
| CHEMBL521350 | — | Ki | = | 45.4 | nM | 7.34 |
| CHEMBL457731 | — | Ki | = | 46.7 | nM | 7.33 |
| CHEMBL458553 | — | Ki | = | 49.2 | nM | 7.31 |
| CHEMBL458361 | — | Ki | = | 71.6 | nM | 7.14 |
| CHEMBL458802 | — | Ki | = | 85.1 | nM | 7.07 |
| CHEMBL457721 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL511507 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL139848 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL75228 | 1-PHENETHYLPIPERIDINE | Ki | = | 595.0 | nM | 6.22 |
| CHEMBL485728 | — | Ki | = | 1710.0 | nM | 5.77 |
| CHEMBL140287 | — | Ki | = | 2640.0 | nM | 5.58 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 7660.0 | nM | 5.12 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | > | 10.0 | nM | - |