Assay Detail
Binding
CHEMBL1000137
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Displacement of [3H]spiroperidol from dopamine D2 receptor in rat striatal membrane
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.85 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487359 | — | — | 1 | 6.11 |
| CHEMBL485929 | — | — | 1 | 6.10 |
| CHEMBL140287 | — | — | 1 | 5.91 |
| CHEMBL487360 | — | — | 1 | 5.88 |
| CHEMBL485729 | — | — | 1 | 5.67 |
| CHEMBL139848 | — | — | 1 | 5.66 |
| CHEMBL485728 | — | — | 1 | 5.62 |
| CHEMBL138900 | — | — | 1 | - |
| CHEMBL521350 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487359 | — | Ki | = | 783.0 | nM | 6.11 |
| CHEMBL485929 | — | Ki | = | 787.0 | nM | 6.10 |
| CHEMBL140287 | — | Ki | = | 1220.0 | nM | 5.91 |
| CHEMBL487360 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL485729 | — | Ki | = | 2120.0 | nM | 5.67 |
| CHEMBL139848 | — | Ki | = | 2190.0 | nM | 5.66 |
| CHEMBL485728 | — | Ki | = | 2380.0 | nM | 5.62 |
| CHEMBL138900 | — | Ki | > | 850.0 | nM | - |
| CHEMBL521350 | — | Ki | > | 850.0 | nM | - |