Assay Detail
Binding
CHEMBL1000303
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Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetric assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.74 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | 4.0 | 1 | 6.89 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.46 |
| CHEMBL455138 | — | — | 1 | 6.28 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 6.12 |
| CHEMBL454936 | — | — | 1 | 6.05 |
| CHEMBL449101 | — | — | 1 | 6.05 |
| CHEMBL507747 | — | — | 1 | 5.96 |
| CHEMBL513796 | — | — | 1 | 5.92 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.85 |
| CHEMBL454937 | — | — | 1 | 5.64 |
| CHEMBL510925 | — | — | 1 | 5.58 |
| CHEMBL455726 | — | — | 1 | 5.48 |
| CHEMBL453108 | — | — | 1 | 5.43 |
| CHEMBL523793 | — | — | 1 | 5.30 |
| CHEMBL455727 | — | — | 1 | 5.22 |
| CHEMBL453124 | — | — | 1 | 5.00 |
| CHEMBL453123 | — | — | 1 | 5.00 |
| CHEMBL508220 | — | — | 1 | 5.00 |
| CHEMBL453109 | — | — | 1 | - |
| CHEMBL490475 | — | — | 1 | - |
| CHEMBL453107 | — | — | 1 | - |
| CHEMBL443773 | — | — | 1 | - |
| CHEMBL462434 | — | — | 1 | - |
| CHEMBL517288 | — | — | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
| CHEMBL461593 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL61 | PODOFILOX | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL455138 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL454936 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL449101 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL507747 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL513796 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL454937 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL510925 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL455726 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL453108 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL523793 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL455727 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL453124 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL453123 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL508220 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL453109 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL490475 | — | IC50 | - | — | - | |
| CHEMBL453107 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL443773 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL462434 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL517288 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL53463 | DOXORUBICIN | IC50 | - | — | - | |
| CHEMBL461593 | — | IC50 | - | — | - |