Assay Detail
ADMET
CHEMBL1000505
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant CYP3A4 expressed in insect microsomes after 45 mins in presence of BZR substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Subcellular | Microsome |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.03 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466555 | — | — | 1 | 6.06 |
| CHEMBL450668 | — | — | 1 | 4.58 |
| CHEMBL454791 | — | — | 1 | 4.44 |
| CHEMBL454751 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466555 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL450668 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL454791 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL454751 | — | IC50 | > | 40000.0 | nM | - |