Assay Detail
Binding
CHEMBL1002069
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Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.38 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421 | SULFASALAZINE | 4.0 | 1 | 5.52 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 5.47 |
| CHEMBL1375 | 5-CHLOROSALICYLIC ACID | — | 1 | 5.39 |
| CHEMBL447810 | — | — | 1 | 5.12 |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | - |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | - |
| CHEMBL448399 | HYDROXYTOLUIC ACID | 2.0 | 1 | - |
| CHEMBL229241 | SULFOSALICYLIC | -1.0 | 1 | - |
| CHEMBL469318 | — | — | 1 | - |
| CHEMBL1169 | AMINOSALICYLIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421 | SULFASALAZINE | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL898 | DIFLUNISAL | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL1375 | 5-CHLOROSALICYLIC ACID | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL447810 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL424 | SALICYLIC ACID | IC50 | = | 560000.0 | nM | - |
| CHEMBL25 | ASPIRIN | IC50 | = | 2710000.0 | nM | - |
| CHEMBL448399 | HYDROXYTOLUIC ACID | IC50 | = | 3070000.0 | nM | - |
| CHEMBL229241 | SULFOSALICYLIC | IC50 | = | 420000.0 | nM | - |
| CHEMBL469318 | — | IC50 | = | 290000.0 | nM | - |
| CHEMBL1169 | AMINOSALICYLIC ACID | IC50 | = | 130000.0 | nM | - |