Assay Detail
Binding
CHEMBL1002071
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Inhibition of human carbonic anhydrase 1 esterase activity by noncompetitive Lineweaver-Burke plot
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.02 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421 | SULFASALAZINE | 4.0 | 1 | 5.16 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 5.07 |
| CHEMBL447810 | — | — | 1 | 4.83 |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | - |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | - |
| CHEMBL1169 | AMINOSALICYLIC ACID | 4.0 | 1 | - |
| CHEMBL448399 | HYDROXYTOLUIC ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421 | SULFASALAZINE | Ki | = | 6870.0 | nM | 5.16 |
| CHEMBL898 | DIFLUNISAL | Ki | = | 8450.0 | nM | 5.07 |
| CHEMBL447810 | — | Ki | = | 14850.0 | nM | 4.83 |
| CHEMBL424 | SALICYLIC ACID | Ki | = | 620000.0 | nM | - |
| CHEMBL25 | ASPIRIN | Ki | = | 7530000.0 | nM | - |
| CHEMBL1169 | AMINOSALICYLIC ACID | Ki | = | 240000.0 | nM | - |
| CHEMBL448399 | HYDROXYTOLUIC ACID | Ki | = | 11420000.0 | nM | - |