Assay Detail
Binding
CHEMBL1002723
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Inhibition of Torpedo californica AChE
22
Total Activities
19
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo californica |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.88 | 10.82 |
| IC50 | 7 | 7.58 | 8.62 |
| Kd | 1 | 4.16 | 4.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL525622 | — | — | 1 | 10.82 |
| CHEMBL117651 | — | — | 1 | 10.11 |
| CHEMBL208599 | HUPRINE X | — | 1 | 9.89 |
| CHEMBL540657 | — | — | 1 | 9.14 |
| CHEMBL483090 | — | — | 2 | 9.10 |
| CHEMBL108696 | — | — | 1 | 8.52 |
| CHEMBL490866 | — | — | 1 | 8.40 |
| CHEMBL519154 | — | — | 2 | 8.35 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 8.24 |
| CHEMBL538358 | DECIDIUM | — | 1 | 7.67 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 7.58 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.40 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 2 | 6.76 |
| CHEMBL245079 | HUPERZINE B | — | 1 | 6.48 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.19 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 5.43 |
| CHEMBL121810 | GANSTIGMINE | 2.0 | 1 | 5.29 |
| CHEMBL360055 | GALLAMINE | 4.0 | 1 | 4.82 |
| CHEMBL1025 | ISOFLUROPHATE | 4.0 | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL525622 | — | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL117651 | — | Ki | = | 0.077 | nM | 10.11 |
| CHEMBL208599 | HUPRINE X | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL540657 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL483090 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL483090 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL108696 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL490866 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL519154 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL519154 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL538358 | DECIDIUM | Ki | = | 21.3 | nM | 7.67 |
| CHEMBL481 | IRINOTECAN | Ki | = | 26.4 | nM | 7.58 |
| CHEMBL95 | TACRINE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL395280 | HUPERZINE A | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL395280 | HUPERZINE A | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL245079 | HUPERZINE B | Ki | = | 334.0 | nM | 6.48 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL345124 | PROPIDIUM | Ki | = | 3730.0 | nM | 5.43 |
| CHEMBL121810 | GANSTIGMINE | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL360055 | GALLAMINE | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL1025 | ISOFLUROPHATE | Kd | = | 70000.0 | nM | 4.16 |