Assay Detail
Functional
CHEMBL1003480
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Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of A-seco derivatives of betulinic acid with cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.72 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520584 | — | — | 1 | 5.05 |
| CHEMBL505945 | — | — | 1 | 4.75 |
| CHEMBL517089 | — | — | 1 | 4.64 |
| CHEMBL431525 | BETUNOLIC ACID | — | 1 | 4.44 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520584 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL505945 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL517089 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL431525 | BETUNOLIC ACID | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 196000.0 | nM | - |