Review anchor
DU-145
CELL-LINE · Homo sapiens
As of 2026-09-14
Evidence Snapshot
DU-145
CHEMBL613508
CELL-LINE
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DU-145 as ChEMBL target CHEMBL613508. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL613508
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-14
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why DU-145 matters
DU-145 is reviewed as DU-145; the current evidence base includes 82 approved drugs, 44268 compounds, and 4098 assays, with lead potency reaching pChEMBL 10.4.
Protein context
DU-145
DU-145
Review this target as DU-145.
Protein source · UniProt accession via ChEMBL component mappingDisease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 82 approved drugs, 44268 compounds, and 4098 assays for this target. The dominant activity type is IC50. CHEMBL1808826 is the current potency anchor at pChEMBL 10.4.
Use CHEMBL1808826 as the tractability anchor when discussing potency (pChEMBL 10.4).
Activity source · ChEMBL 36 via Core Engine
82 approved
pChEMBL 10.4
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why DU-145 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
44268
Total Compounds
4098
Total Assays
82
Approved Drugs
IC50: 9031.0, EC50: 206.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL1808826
|
10.4 | IC50 | — |
|
|
No preferred name
CHEMBL159
|
10.2 | IC50 | Approved |
|
|
No preferred name
CHEMBL92
|
10.0 | IC50 | Approved |
|
|
No preferred name
CHEMBL269081
|
10.0 | IC50 | — |
|
|
No preferred name
CHEMBL1808824
|
9.8 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
MIDOSTAURIN
CHEMBL608533
|
2017 |
|
|
AFATINIB
CHEMBL1173655
|
2013 |
|
|
TEMSIROLIMUS
CHEMBL1201182
|
2007 |
|
|
VORINOSTAT
CHEMBL98
|
2006 |
|
|
DASATINIB
CHEMBL5416410
|
2006 |
|
|
ERLOTINIB
CHEMBL553
|
2004 |
|
|
GEFITINIB
CHEMBL939
|
2003 |
|
|
TOPOTECAN
CHEMBL84
|
1996 |
|
|
IRINOTECAN
CHEMBL481
|
1996 |
|
|
GEMCITABINE
CHEMBL888
|
1996 |
|
|
DOCETAXEL ANHYDROUS
CHEMBL92
|
1995 |
|
|
DOCETAXEL
CHEMBL3545252
|
1995 |
|
|
VINORELBINE
CHEMBL553025
|
1994 |
|
|
PACLITAXEL
CHEMBL428647
|
1992 |
|
|
PODOFILOX
CHEMBL61
|
1990 |
|
|
MITOXANTRONE
CHEMBL58
|
1987 |
|
|
AMSACRINE
CHEMBL43
|
1987 |
|
|
ETOPOSIDE
CHEMBL44657
|
1983 |
|
|
NICLOSAMIDE
CHEMBL1448
|
1982 |
|
|
DIGITOXIN
CHEMBL254219
|
1982 |
|
|
MITOMYCIN
CHEMBL105
|
1981 |
|
|
DAUNORUBICIN
CHEMBL178
|
1979 |
|
|
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
|
1974 |
|
|
DOXORUBICIN
CHEMBL53463
|
1974 |
|
|
VINBLASTINE
CHEMBL159
|
1965 |
|
|
DACTINOMYCIN
CHEMBL1554
|
1964 |
|
|
VINCRISTINE SULFATE
CHEMBL501867
|
1963 |
|
|
VINCRISTINE
CHEMBL90555
|
1963 |
|
|
FLUOROURACIL
CHEMBL185
|
1962 |
|
|
COLCHICINE
CHEMBL107
|
1961 |
|
|
METHOTREXATE
CHEMBL34259
|
1953 |
|
|
EMETINE
CHEMBL50588
|
— |
Source Header