Assay Detail
Binding
CHEMBL1004447
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of aldose reductase in rat lens homogenates by fluorophotometer
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.07 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 7.14 |
| CHEMBL499959 | — | — | 1 | 5.01 |
| CHEMBL226335 | RUTIN | 3.0 | 1 | 4.89 |
| CHEMBL446488 | — | — | 1 | 4.75 |
| CHEMBL499824 | — | — | 1 | 4.75 |
| CHEMBL485261 | — | — | 1 | 4.72 |
| CHEMBL504221 | PRUNOSE I | — | 1 | 4.24 |
| CHEMBL453506 | PRUNOSE II | — | 1 | - |
| CHEMBL444468 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56337 | EPALRESTAT | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL499959 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL226335 | RUTIN | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL446488 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL499824 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL485261 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL504221 | PRUNOSE I | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL453506 | PRUNOSE II | IC50 | > | 100000.0 | nM | - |
| CHEMBL444468 | — | IC50 | > | 30000.0 | nM | - |