Assay Detail
Functional
CHEMBL1005097
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Cytotoxicity against mouse EN2 cells after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | EN2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Stereochemistry-dependent cytotoxicity of some artemisinin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.44 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL498923 | — | — | 1 | 6.96 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 6.01 |
| CHEMBL504767 | — | — | 1 | 5.70 |
| CHEMBL448034 | — | — | 1 | 5.05 |
| CHEMBL465345 | — | — | 1 | 4.90 |
| CHEMBL2093993 | — | — | 1 | 4.00 |
| CHEMBL516712 | — | — | 1 | - |
| CHEMBL331309 | DEOXYARTEMISININ | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL498923 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL504767 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL448034 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL465345 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL2093993 | — | IC50 | = | 99800.0 | nM | 4.00 |
| CHEMBL516712 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL331309 | DEOXYARTEMISININ | IC50 | = | 111000.0 | nM | - |