Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1005603

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membrane
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mu-type opioid receptor (CHEMBL233)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and pharmacological evaluation of hydrophobic esters and ethers of butorphanol at opioid receptors.
Fulton BS, Knapp BI, Bidlack JM, Neumeyer JL.
Bioorg Med Chem Lett (2008) 18 : 4474 -4476
PubMed 18674902 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 8.65 10.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL500419 1 10.21
CHEMBL592 LEVORPHANOL 4.0 1 9.68
CHEMBL521543 1 9.66
CHEMBL33986 BUTORPHANOL 4.0 1 9.66
CHEMBL301160 BUTORPHAN 1 9.64
CHEMBL501739 1 9.49
CHEMBL500154 1 8.64
CHEMBL503457 1 8.57
CHEMBL499868 1 8.41
CHEMBL499884 1 8.17
CHEMBL501447 1 8.00
CHEMBL451320 1 7.82
CHEMBL526362 1 7.80
CHEMBL500123 1 7.75
CHEMBL524505 1 7.68
CHEMBL497108 1 7.26

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL500419 Ki = 0.061 nM 10.21
CHEMBL592 LEVORPHANOL Ki = 0.21 nM 9.68
CHEMBL521543 Ki = 0.22 nM 9.66
CHEMBL33986 BUTORPHANOL Ki = 0.22 nM 9.66
CHEMBL301160 BUTORPHAN Ki = 0.23 nM 9.64
CHEMBL501739 Ki = 0.32 nM 9.49
CHEMBL500154 Ki = 2.3 nM 8.64
CHEMBL503457 Ki = 2.7 nM 8.57
CHEMBL499868 Ki = 3.9 nM 8.41
CHEMBL499884 Ki = 6.7 nM 8.17
CHEMBL501447 Ki = 10.0 nM 8.00
CHEMBL451320 Ki = 15.0 nM 7.82
CHEMBL526362 Ki = 16.0 nM 7.80
CHEMBL500123 Ki = 18.0 nM 7.75
CHEMBL524505 Ki = 21.0 nM 7.68
CHEMBL497108 Ki = 55.0 nM 7.26