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Assay Detail

CHEMBL1006579

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Binding
Inhibition of human Wee1
ChEMBL ↗
338
Total Activities
169
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Wee1-like protein kinase (CHEMBL5491) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors.
Wichapong K, Lindner M, Pianwanit S, Kokpol S, Sippl W.
Eur J Med Chem (2009) 44 : 1383 -1395
PubMed 18976834 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 338 6.96 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL472542 — — 2 8.22
CHEMBL471163 — — 2 8.15
CHEMBL515352 — — 2 8.15
CHEMBL471157 — — 2 8.10
CHEMBL459889 — — 2 8.05
CHEMBL411662 — — 2 8.05
CHEMBL486517 — — 2 8.05
CHEMBL379975 — — 2 7.96
CHEMBL460940 — — 2 7.92
CHEMBL213313 — — 2 7.92
CHEMBL213585 — — 2 7.92
CHEMBL215815 — — 2 7.89
CHEMBL461116 — — 2 7.85
CHEMBL472689 — — 2 7.82
CHEMBL271715 — — 2 7.82
CHEMBL215485 — — 2 7.82
CHEMBL511280 — — 2 7.82
CHEMBL471329 — — 2 7.80
CHEMBL386048 — — 2 7.75
CHEMBL469822 — — 2 7.75
CHEMBL384089 — — 2 7.72
CHEMBL487757 — — 2 7.72
CHEMBL258067 — — 2 7.72
CHEMBL378066 — — 2 7.70
CHEMBL211140 — — 2 7.70
CHEMBL474714 — — 2 7.70
CHEMBL484808 — — 2 7.68
CHEMBL512342 — — 2 7.68
CHEMBL520182 — — 2 7.64
CHEMBL213367 — — 2 7.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL472542 — IC50 = 6.026 nM 8.22
CHEMBL472542 — IC50 = 6.0 nM 8.22
CHEMBL471163 — IC50 = 7.0 nM 8.15
CHEMBL515352 — IC50 = 7.0 nM 8.15
CHEMBL515352 — IC50 = 7.079 nM 8.15
CHEMBL471163 — IC50 = 7.079 nM 8.15
CHEMBL471157 — IC50 = 8.0 nM 8.10
CHEMBL471157 — IC50 = 7.943 nM 8.10
CHEMBL411662 — IC50 = 9.0 nM 8.05
CHEMBL459889 — IC50 = 9.0 nM 8.05
CHEMBL486517 — IC50 = 9.0 nM 8.05
CHEMBL486517 — IC50 = 8.913 nM 8.05
CHEMBL411662 — IC50 = 8.913 nM 8.05
CHEMBL379975 — IC50 = 10.96 nM 7.96
CHEMBL379975 — IC50 = 11.0 nM 7.96
CHEMBL460940 — IC50 = 12.02 nM 7.92
CHEMBL460940 — IC50 = 12.0 nM 7.92
CHEMBL213585 — IC50 = 12.0 nM 7.92
CHEMBL213313 — IC50 = 12.02 nM 7.92
CHEMBL215815 — IC50 = 13.0 nM 7.89
CHEMBL459889 — IC50 = 12.88 nM 7.89
CHEMBL215815 — IC50 = 12.88 nM 7.89
CHEMBL461116 — IC50 = 14.0 nM 7.85
CHEMBL461116 — IC50 = 14.13 nM 7.85
CHEMBL511280 — IC50 = 15.14 nM 7.82
CHEMBL215485 — IC50 = 15.14 nM 7.82
CHEMBL215485 — IC50 = 15.0 nM 7.82
CHEMBL472689 — IC50 = 15.14 nM 7.82
CHEMBL271715 — IC50 = 15.14 nM 7.82
CHEMBL511280 — IC50 = 15.0 nM 7.82
CHEMBL472689 — IC50 = 15.0 nM 7.82
CHEMBL271715 — IC50 = 15.0 nM 7.82
CHEMBL471329 — IC50 = 15.85 nM 7.80
CHEMBL471329 — IC50 = 16.0 nM 7.80
CHEMBL386048 — IC50 = 18.0 nM 7.75
CHEMBL469822 — IC50 = 18.0 nM 7.75
CHEMBL469822 — IC50 = 18.2 nM 7.74
CHEMBL386048 — IC50 = 18.2 nM 7.74
CHEMBL487757 — IC50 = 19.0 nM 7.72
CHEMBL384089 — IC50 = 19.05 nM 7.72
CHEMBL258067 — IC50 = 19.0 nM 7.72
CHEMBL384089 — IC50 = 19.0 nM 7.72
CHEMBL258067 — IC50 = 19.05 nM 7.72
CHEMBL487757 — IC50 = 19.05 nM 7.72
CHEMBL211140 — IC50 = 19.95 nM 7.70
CHEMBL474714 — IC50 = 19.95 nM 7.70
CHEMBL474714 — IC50 = 20.0 nM 7.70
CHEMBL378066 — IC50 = 19.95 nM 7.70
CHEMBL211140 — IC50 = 20.0 nM 7.70
CHEMBL378066 — IC50 = 20.0 nM 7.70