Compound Detail
CHEMBL520182
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL520182 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FLXRKROAYLDNNO-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
324.3
MW (Da)
1.86
ALogP
5
HBA
3
HBD
108.6
PSA (Ų)
0.64
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Wee1-like protein kinase CHEMBL5491 | IC50 | 7.64 | 7.64 | 22.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Wee1-like protein kinase | IC50 | = | 22.91 | nM | 7.64 | Inhibition of human Wee1 | 18976834 |
| Wee1-like protein kinase | IC50 | = | 23.0 | nM | 7.64 | Inhibition of human Wee1 | 18976834 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18976834 | 10.1016/j.ejmech.2008.09.027 | Wee1-like protein kinase | 2 |
Data from ChEMBL 36 via Core Engine