Assay Detail
Functional
CHEMBL1007026
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of apoptosis in human T47D cells assessed as caspase activation by HTS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl-N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.25 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460601 | — | — | 1 | 7.43 |
| CHEMBL496732 | — | — | 1 | 7.14 |
| CHEMBL495560 | — | — | 1 | 6.85 |
| CHEMBL495768 | — | — | 1 | 6.62 |
| CHEMBL451938 | — | — | 1 | 6.42 |
| CHEMBL495912 | — | — | 1 | 6.38 |
| CHEMBL495911 | — | — | 1 | 6.33 |
| CHEMBL495561 | — | — | 1 | 6.29 |
| CHEMBL521706 | — | — | 1 | 6.23 |
| CHEMBL460602 | — | — | 1 | 6.09 |
| CHEMBL495910 | — | — | 1 | 5.89 |
| CHEMBL496939 | — | — | 1 | 5.58 |
| CHEMBL495562 | — | — | 1 | 5.36 |
| CHEMBL495978 | — | — | 1 | 4.92 |
| CHEMBL498210 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460601 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL496732 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL495560 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL495768 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL451938 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL495912 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL495911 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL495561 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL521706 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL460602 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL495910 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL496939 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL495562 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL495978 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL498210 | — | EC50 | > | 10000.0 | nM | - |