Assay Detail
Binding
CHEMBL1007647
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Inhibition of bovine thrombin-catalyzed hydrolysis of S-2238
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.83 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510512 | TELLIMAGRANDIN II | — | 1 | 7.16 |
| CHEMBL382408 | PENTAGALLOYL GLUCOSE | — | 1 | 6.96 |
| CHEMBL506204 | PEDUNCULAGIN | — | 1 | 6.75 |
| CHEMBL488110 | — | — | 1 | 6.72 |
| CHEMBL509562 | CASUARIIN | — | 1 | 6.55 |
| CHEMBL458684 | — | — | 1 | - |
| CHEMBL458193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510512 | TELLIMAGRANDIN II | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL382408 | PENTAGALLOYL GLUCOSE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL506204 | PEDUNCULAGIN | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL488110 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL509562 | CASUARIIN | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL458684 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL458193 | — | IC50 | > | 200000.0 | nM | - |