Assay Detail
Binding
CHEMBL1008047
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique
44
Total Activities
44
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Small conductance calcium-activated potassium channel protein 3 (CHEMBL3780) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 40 | 6.65 | 9.37 |
| Activity | 3 | - | - |
| IC50 | 1 | 5.16 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420873 | — | — | 1 | 9.37 |
| CHEMBL117908 | — | — | 1 | 8.57 |
| CHEMBL511710 | — | — | 1 | 8.04 |
| CHEMBL504041 | — | — | 1 | 7.96 |
| CHEMBL458836 | — | — | 1 | 7.77 |
| CHEMBL463987 | — | — | 1 | 7.70 |
| CHEMBL463373 | — | — | 1 | 7.57 |
| CHEMBL453140 | — | — | 1 | 7.51 |
| CHEMBL463189 | — | — | 1 | 7.50 |
| CHEMBL463986 | — | — | 1 | 7.48 |
| CHEMBL511681 | — | — | 1 | 7.47 |
| CHEMBL457743 | — | — | 1 | 7.36 |
| CHEMBL511709 | — | — | 1 | 7.21 |
| CHEMBL510780 | — | — | 1 | 7.11 |
| CHEMBL457744 | — | — | 1 | 6.92 |
| CHEMBL458755 | — | — | 1 | 6.89 |
| CHEMBL487165 | — | — | 1 | 6.89 |
| CHEMBL444117 | — | — | 1 | 6.77 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | 4.0 | 1 | 6.75 |
| CHEMBL456444 | — | — | 1 | 6.70 |
| CHEMBL486156 | — | — | 1 | 6.35 |
| CHEMBL487166 | — | — | 1 | 6.27 |
| CHEMBL458754 | — | — | 1 | 6.23 |
| CHEMBL519876 | — | — | 1 | 6.22 |
| CHEMBL456445 | — | — | 1 | 6.19 |
| CHEMBL507161 | — | — | 1 | 6.12 |
| CHEMBL458756 | — | — | 1 | 6.10 |
| CHEMBL515502 | — | — | 1 | 5.80 |
| CHEMBL453486 | — | — | 1 | 5.77 |
| CHEMBL457972 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420873 | — | Kd | = | 0.43 | nM | 9.37 |
| CHEMBL117908 | — | Kd | = | 2.7 | nM | 8.57 |
| CHEMBL511710 | — | Kd | = | 9.1 | nM | 8.04 |
| CHEMBL504041 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL458836 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL463987 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL463373 | — | Kd | = | 27.0 | nM | 7.57 |
| CHEMBL453140 | — | Kd | = | 31.0 | nM | 7.51 |
| CHEMBL463189 | — | Kd | = | 32.0 | nM | 7.50 |
| CHEMBL463986 | — | Kd | = | 33.0 | nM | 7.48 |
| CHEMBL511681 | — | Kd | = | 34.0 | nM | 7.47 |
| CHEMBL457743 | — | Kd | = | 44.0 | nM | 7.36 |
| CHEMBL511709 | — | Kd | = | 61.0 | nM | 7.21 |
| CHEMBL510780 | — | Kd | = | 77.0 | nM | 7.11 |
| CHEMBL457744 | — | Kd | = | 120.0 | nM | 6.92 |
| CHEMBL458755 | — | Kd | = | 130.0 | nM | 6.89 |
| CHEMBL487165 | — | Kd | = | 130.0 | nM | 6.89 |
| CHEMBL444117 | — | Kd | = | 170.0 | nM | 6.77 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | Kd | = | 180.0 | nM | 6.75 |
| CHEMBL456444 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL486156 | — | Kd | = | 450.0 | nM | 6.35 |
| CHEMBL487166 | — | Kd | = | 540.0 | nM | 6.27 |
| CHEMBL458754 | — | Kd | = | 590.0 | nM | 6.23 |
| CHEMBL519876 | — | Kd | = | 600.0 | nM | 6.22 |
| CHEMBL456445 | — | Kd | = | 640.0 | nM | 6.19 |
| CHEMBL507161 | — | Kd | = | 750.0 | nM | 6.12 |
| CHEMBL458756 | — | Kd | = | 790.0 | nM | 6.10 |
| CHEMBL515502 | — | Kd | = | 1600.0 | nM | 5.80 |
| CHEMBL453486 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL457972 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL215370 | LAUDANOSINE METHIODIDE | Kd | = | 2600.0 | nM | 5.58 |
| CHEMBL456446 | — | Kd | = | 2700.0 | nM | 5.57 |
| CHEMBL1360 | ATRACURIUM | Kd | = | 6400.0 | nM | 5.19 |
| CHEMBL455001 | — | Kd | = | 6500.0 | nM | 5.19 |
| CHEMBL558625 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL539935 | — | Kd | = | 14000.0 | nM | 4.85 |
| CHEMBL1687 | — | Kd | = | 16000.0 | nM | 4.80 |
| CHEMBL554917 | PENUCURONIUM | Kd | = | 21000.0 | nM | 4.68 |
| CHEMBL502867 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL453730 | — | Activity | - | — | - | |
| CHEMBL499968 | — | Activity | - | — | - | |
| CHEMBL452887 | — | Activity | - | — | - | |
| CHEMBL171596 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL486569 | — | Kd | > | 10000.0 | nM | - |